HuDSeN:277

SOX2 SRY (sex determining region Y)-box 2(NM_003106)
CS CS19
in situ hybridisation

Data Images
HuDSeN:277 HuDSeN:277 HuDSeN:277 HuDSeN:277 HuDSeN:277
Expression pattern clarity: three stars
Detection Reagent
Type:in situ hybridisation probe
Identifier:SOX2
Entity Detected:SOX2, SRY (sex determining region Y)-box 2(NM_003106)
Notes:697-bp fragment from the 3' untranslated region
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:human
Carnegie Stage:CS19
Preparation:section
Expression Pattern Description
Text Annotation:
StructureLevelPatternNotes
eye
strong strong
not applicableSections 805_08, 805_12
forebrain
strong strong
not applicableSections 805_12, 805_35, 805_37, 805_45
hindbrain
strong strong
not applicableSections 805_12, 805_35, 805_37, 805_45
midbrain
strong strong
not applicableSections 805_35, 805_37, 805_45
Procedures
Fixation:4% paraformaldehyde
Staining procedure:alkaline phosphatase + NBT/BCIP
General Information
Principal investigator:Prof Mehul Dattani, Institute of Child Health, Clinical and Molecular Genetics Unit, 30 Guildford Street, London, UK WC1N 1EH
Submitted by:Janet Kerwin, Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK NE1 3BZ
Experiment type:non-screen
References:PMID: 18285410 Kelberman D, de Castro SC, Huang S, Crolla JA, Palmer R, Gregory JW, Taylor D, Cavallo L, Faienza MF, Fischetto R, Achermann JC, Martinez-Barbera JP, Rizzoti K, Lovell-Badge R, Robinson IC, Gerrelli D, Dattani MT 2008 SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development J Clin Endocrinol Metab (93):1865-73
Acknowledgments:The human embryonic material was provided by the Joint MRC-Wellcome Trust Human Developmental Biology Resource (http://www.hdbr.org) at the IHG, Newcastle-upon-Tyne, UK
Links: EMAGE same gene
  Allen Brain Atlas same gene
  BioGPS same gene

Entries are submitted to the HuDSeN database using the official gene name, according to the HUGO Gene Nomenclature Committee, at the time of uploading. If an official gene name subsequently changes after submission of the entry to the database, the previous name may be shown in the table above.


Copyright ©The Medical Research Council & University of Newcastle
All Rights Reserved.